Flavohemoglobins (FHbs) are members of the globin superfamily, widely distributed among
prokaryotes and eukaryotes that have been shown to carry out nitric oxide dioxygenase
(NOD) activity. In prokaryotes, such as Escherichia coli, NOD activity is a defence
mechanism against the NO release by the macrophages of the hosts' immune system during
infection. Because of that, FHbs have been studied thoroughly and several drugs have been
developed in an effort to fight infectious processes. Nevertheless, the protein's structural …